A client taking ketoconazole 250 mg PO daily reports nausea and anorexia. What is the nurse's best action?

The suggestion to try small, frequent meals is a sound approach for managing the nausea and anorexia that the client is experiencing while on ketoconazole. This strategy can help alleviate gastrointestinal side effects by providing a gentler approach to food intake. Instead of overwhelming the stomach with large meals, smaller portions can help ensure that the client still receives adequate nutrition without exacerbating their symptoms.

Offering food choices throughout the day rather than a few large meals can also enhance the absorption of the medication, which is essential for its effectiveness in treating fungal infections. Ketoconazole can cause gastrointestinal irritation, and allowing the client to eat smaller meals may help mitigate this side effect while still enabling them to continue the necessary treatment for their condition.

It's important to monitor the client's overall response to treatment and educate them on the use of small, frequent meals, as this can lead to improved comfort and adherence to the medication regimen.