How should fluconazole be administered for maximum effectiveness?

Fluconazole is best absorbed when taken on an empty stomach. When administered in this manner, the medication's bioavailability can be maximized, allowing it to work more effectively against fungal infections. Foods can sometimes interfere with the absorption of certain medications, including antifungals, which is why taking fluconazole without food is recommended for optimal therapeutic effect.

While it is true that the drug can still be effective if taken with food, the potential reduction in absorption when consumed with meals is significant enough to favor taking it without food. The other options, such as taking it with a full meal or with vitamin supplements, do not provide the ideal conditions for absorption. Timing the administration in the evening can also be irrelevant to its effectiveness, as the primary concern remains the presence of food in the gastrointestinal tract.