What are common indications for using amphotericin B?

Amphotericin B is primarily indicated for severe fungal infections due to its broad-spectrum antifungal properties and effectiveness against a wide range of fungal pathogens. This polyene antifungal agent is often used to treat serious infections caused by organisms such as Candida species and Aspergillus species, particularly in immunocompromised patients or those with life-threatening systemic fungal infections. Its mechanism involves binding to ergosterol in fungal cell membranes, leading to increased membrane permeability and ultimately cell death.

In contrast, minor fungal infections can typically be managed with less potent antifungal agents, and amphotericin B is not utilized for superficial infections like skin or mucosal candidiasis, which often respond well to topical treatments or oral azoles. Additionally, amphotericin B is not indicated for allergy treatment; it is strictly an antifungal medication. Thus, the correct indication of severe fungal infections highlights the drug's importance in managing life-threatening conditions associated with significant morbidity and mortality.