What condition is amphotericin B often used to treat, aside from systemic fungal infections?

Amphotericin B is an antifungal agent that is particularly effective in treating a variety of systemic fungal infections. One of the less common but significant conditions it is often used for is leishmaniasis, which is a parasitic disease caused by protozoan parasites of the Leishmania species. This treatment is important because amphotericin B exerts its effects by binding to ergosterol in fungal cell membranes, which disrupts membrane integrity and leads to cell death.

In the case of leishmaniasis, while it is a parasitic infection rather than a fungal one, the drug's effectiveness in treating certain forms of this condition has established its use in clinical settings, especially in severe or refractory cases.

Other options, such as those related to systemic fungal infections, are indeed common indications for amphotericin B; however, leishmaniasis represents a unique and specific use of this medication, showcasing its versatility in treating complex infections.