What is a common side effect of amphotericin B?

Amphotericin B is known for its potential to cause infusion-related reactions, which are among the most common side effects experienced by patients receiving this antifungal agent. These reactions can include symptoms such as fever, chills, rigors, and headache, occurring typically during or shortly after the infusion. The mechanism behind these reactions is thought to involve the release of pro-inflammatory cytokines and is especially notable with the conventional formulation of amphotericin B.

Other options, while they may occur in specific cases, are less commonly associated with amphotericin B. For example, hyperkalemia and rash can occur but are not as prevalent or characteristic as the infusion-related reactions. Constipation is not a notable side effect associated with amphotericin B. Understanding the common side effects like infusion-related reactions is essential for managing patient care during antifungal therapy, as it allows healthcare providers to anticipate and mitigate these effects.