What is a potential adverse effect of long-term fluconazole therapy?

Long-term therapy with fluconazole can lead to liver toxicity, which is a significant concern when using this antifungal agent over extended periods. Fluconazole is metabolized by the liver, and prolonged use can cause elevations in liver enzymes, indicating potential liver damage. Patients on long-term fluconazole therapy are often monitored for hepatic function to catch any adverse effects early.

Although the other options may be relevant concerns in different contexts or medications, they are not typically associated with the long-term use of fluconazole. Weight gain and heart palpitations are not common side effects related to fluconazole, while fractures might be linked to different underlying conditions rather than the medication itself. Thus, the risk of liver toxicity stands out as a notable adverse effect in the context of long-term fluconazole use.