What is a significant risk associated with the use of Amphotericin B?

Amphotericin B is known for its potential to cause nephrotoxicity, which is a significant risk in patients receiving this antifungal medication. This toxicity arises because Amphotericin B interacts with kidney cells, leading to renal impairment and electrolyte imbalances, particularly hypokalemia and hypomagnesemia. Monitoring kidney function through serum creatinine levels and electrolytes is crucial during treatment to identify any early signs of kidney damage.

While Amphotericin B can have effects on other organ systems, nephrotoxicity is the most well-documented and clinically significant adverse effect, making it a primary concern when prescribing this medication.