What is a significant side effect that may occur with ketoconazole therapy?

Ketoconazole is an antifungal agent that is particularly known for its potential to cause liver toxicity. One of the significant side effects of ketoconazole therapy is the elevation of liver enzymes, which is a marker of liver injury or dysfunction. This may result from the drug's metabolism through the liver and its potential to cause hepatotoxicity.

Monitoring liver function tests during ketoconazole treatment is essential, especially in patients with pre-existing liver conditions or when used in conjunction with other hepatotoxic drugs. Elevated liver enzymes can indicate ongoing liver damage, and in severe cases, may lead to liver failure, warranting discontinuation of the drug.

While the other side effects mentioned may be associated with other medications or conditions, they are not hallmark responses specifically tied to ketoconazole as much as elevated liver enzymes are. Thus, the prominent concern with ketoconazole therapy revolves around the risk of liver enzyme elevation, making it a critical aspect of management when prescribing this medication.