What is the common reaction that may occur with amphotericin B infusion?

Amphotericin B is an antifungal agent known for its potent efficacy against a variety of fungal infections. One common reaction that can occur during the infusion of amphotericin B is the occurrence of fevers and chills. This infusion-related reaction is primarily due to the drug's interaction with immune responses.

When amphotericin B is administered, it can stimulate the release of cytokines, leading to systemic inflammatory responses. These responses commonly manifest as fever and chills, resembling a flu-like syndrome. This reaction can occur with the initial doses and may decrease with subsequent infusions as the patient becomes accustomed to the medication.

Understanding this side effect is important for managing patient comfort and recognizing that these reactions are generally predictable and often manageable with premedications like antipyretics or antihistamines. While nausea and vomiting, skin rashes, or increased heart rate can also occur with various medications, they are not the hallmark reactions specifically associated with amphotericin B infusion. Instead, the significant incidence of fevers and chills stands out in the context of its administration.