What is the pregnancy category of fluconazole?

Fluconazole is classified as a Category D medication in pregnancy. This designation means that there is positive evidence of human fetal risk based on data from adverse reaction reports or studies in humans. While fluconazole has demonstrated efficacy in treating fungal infections, its use during pregnancy has been associated with potential teratogenic effects, particularly when given in high doses or during the first trimester.

This categorization is particularly important for healthcare providers when considering treatment options for pregnant patients, as the benefits of fluconazole must be weighed against its risks to fetal development. In practice, this means that while fluconazole can be a critical option for certain severe fungal infections, prescribers must proceed with caution and provide patients with relevant information regarding the risks involved.

In contrast, the other categories suggest varying levels of risk that do not align with fluconazole's established safety profile in pregnant individuals.