What is the primary route of administration for amphotericin B?

Amphotericin B is primarily administered intravenously because it is poorly absorbed from the gastrointestinal tract. This means that oral administration would not achieve adequate systemic levels necessary for antifungal efficacy. Intravenous administration allows for direct entry into the bloodstream, ensuring that the drug can effectively reach its target sites to combat systemic fungal infections.

Additionally, amphotericin B is often used in the treatment of severe fungal infections such as cryptococcal meningitis and systemic candidiasis, where rapid and high systemic concentrations are needed. Other routes of administration, such as topically or via inhalation, may not deliver the drug effectively enough to treat these serious conditions. Therefore, the intravenous route is the standard and most effective method for utilizing amphotericin B in clinical settings.