What is the primary target of allylamine antifungals?

Allylamine antifungals primarily target the fungal cell membrane, specifically by inhibiting the enzyme squalene epoxidase. This inhibition disrupts the biosynthesis of ergosterol, an essential component of the fungal cell membrane. Without adequate ergosterol, the cell membrane becomes compromised, leading to increased membrane permeability and ultimately causing cell lysis. This mode of action is distinct from other antifungal classes that may target different components of the fungal cell. By focusing on the cell membrane, allylamines effectively exert their antifungal effects, making them valuable in the treatment of fungal infections.