What key change in a client's health status should be reported if the client is being treated with ketoconazole?

Reporting elevated AST and ALT levels in a client being treated with ketoconazole is critical because it indicates potential liver toxicity or hepatic impairment. Ketoconazole, an antifungal agent, can have hepatotoxic effects, leading to an increase in liver enzymes due to liver inflammation or damage. Monitoring liver function tests is essential in patients on this medication to ensure early detection of any adverse effects. Elevated enzyme levels signal that the liver is under stress and may not be metabolizing drugs appropriately, which could lead to serious complications if not addressed.

In contrast, changes such as increased appetite, improved energy levels, or decreased liver enzymes may not necessarily indicate problems requiring immediate attention. Increased appetite and improved energy levels could reflect the intended therapeutic effect of the medication, while decreased liver enzymes would be a positive development suggesting that liver function is returning to normal. Therefore, it's crucial to focus on the rise in AST and ALT levels as a significant health status change needing to be reported.