What should a nurse discuss with the prescriber regarding amphotericin B if the order states 60 mg PO daily?

When evaluating the order for amphotericin B at a dosage of 60 mg PO (by mouth) daily, it is essential to discuss the route of administration with the prescriber. Amphotericin B is typically administered via intravenous infusion due to its poor oral bioavailability. The medication is designed to be given intravenously to ensure that adequate therapeutic levels are achieved in the bloodstream for effective antifungal activity. Therefore, the order for oral administration is likely inappropriate.

Addressing this with the prescriber is crucial because administering amphotericin B orally could lead to insufficient treatment of fungal infections, as the drug would not reach effective concentrations in the body if taken by mouth. Clarity on the preferred and most effective route of administration ensures that the patient receives the correct treatment and optimizes therapeutic outcomes.