What should the nurse inform a client undergoing treatment with amphotericin B who reports fevers and chills about one hour into the infusion?

The response that indicates the fevers and chills are a common reaction to amphotericin B is grounded in the understanding of how the body reacts to this antifungal agent. Amphotericin B can provoke an infusion-related reaction, often characterized by symptoms like fevers, chills, headache, nausea, and rigors. This is attributed to the drug's mechanism, as it interacts with cell membranes, potentially triggering an immune response.

These symptoms typically occur during the initial infusions, especially if the patient has not been premedicated with antipyretics, antihistamines, or steroids, which may be done to mitigate such reactions. Informing the patient that these are common occurrences helps set realistic expectations and can reassure them about the treatment process, fostering a cooperative patient-nurse relationship.

Patient education regarding these reactions is vital as it enables the client to distinguish between expected and atypical reactions, thereby ensuring they feel more comfortable and informed during their treatment.