When caring for a client receiving amphotericin B, what condition should the nurse assess for?

Amphotericin B is a powerful antifungal agent commonly used to treat severe fungal infections. One of the significant side effects associated with amphotericin B is the development of phlebitis, particularly when it is administered via intravenous infusion. Assessing for phlebitis is crucial because this condition can lead to local inflammation, discomfort, and potential complications at the infusion site.

Phlebitis occurs due to irritation of the blood vessels, which can be exacerbated by the infusion of certain medications, including amphotericin B. Signs of phlebitis may include redness, swelling, warmth, and tenderness over the vein where the drug is being infused. Monitoring for phlebitis ensures timely intervention to manage symptoms and prevent more serious complications, such as thrombosis or infection.

While renal failure is indeed a potential concern with amphotericin B due to its nephrotoxic effects, the direct assessment of site condition related to drug administration focuses more on monitoring for phlebitis. Hepatitis and skin rash are not typically the primary focus in the context of immediate assessment during amphotericin B therapy, thus reinforcing the importance of focusing on phlebitis as a critical monitoring point.