When might a nurse consider discontinuing fluconazole treatment for a patient?

Discontinuing fluconazole treatment may be considered if the patient exhibits jaundice. Jaundice is a significant clinical sign indicating potential liver dysfunction or damage, which can be serious. Fluconazole, as well as other antifungal agents, is primarily metabolized in the liver, and any impairment in liver function can lead to elevated drug levels, increasing the risk of hepatotoxicity. The presence of jaundice suggests that the patient's liver may not be processing medications appropriately, and continuing treatment could exacerbate liver injury or lead to further complications.

In contrast, while persistent headache, diarrhea, and fatigue can be side effects associated with fluconazole, they are generally less concerning and may not warrant discontinuation unless they are severe or worsen the patient's overall health status. Monitoring and management of these side effects may be more appropriate, up to and including adjustments in dosage or supportive care. Thus, jaundice stands out as a critical indicator that requires immediate reevaluation of the treatment plan.