Which antifungal agent is commonly used for oropharyngeal candidiasis?

Nystatin is commonly used for the treatment of oropharyngeal candidiasis due to its effectiveness against Candida species, which are the primary causative organisms of this condition. Nystatin is a polyene antifungal that works by binding to ergosterol, a key component of fungal cell membranes, leading to increased membrane permeability and ultimately cell death.

Its topical formulation is specifically devised for localized infections, making it particularly suitable for oropharyngeal lesions. The oral suspension form of Nystatin is also readily administered for this type of candidiasis, allowing for direct placement in the mouth and throat to treat infections effectively.

Other antifungal agents like fluconazole are indeed used for candidiasis, especially in cases requiring systemic therapy or more resistant infections, but for mild cases like oropharyngeal candidiasis, Nystatin is the preferred choice due to its targeted application and safety profile. Amphotericin B, while highly effective for severe systemic fungal infections, is less commonly used for localized conditions due to its toxicity and the need for intravenous administration. Voriconazole is generally indicated for invasive aspergillosis and some resistant strains of Candida but is not the first-line treatment for uncomplicated oropharyngeal candidiasis.