Which antifungal agent is often used in combination with other drugs to enhance efficacy against resistant infections?

Amphotericin B is frequently employed in combination with other antifungal agents to improve treatment outcomes, particularly in cases of severe fungal infections or when dealing with resistant strains. This polyene antibiotic works by binding to ergosterol in the fungal cell membrane, creating pores that lead to cell death. Its broad spectrum of activity against various fungi, including molds and yeasts, makes it a valuable choice in combination therapy.

Combining Amphotericin B with azoles like fluconazole or voriconazole can enhance efficacy and help overcome resistance mechanisms that some fungi may have developed. The synergistic effect seen when used alongside other antifungals can result in improved clinical outcomes, especially for infections like invasive aspergillosis or cryptococcal meningitis.

In contrast, while fluconazole, micafungin, and voriconazole are effective antifungals on their own and can be used for a variety of infections, they are often not utilized in combination as frequently as Amphotericin B to combat resistance. Each of these agents has its own spectrum of activity and potential limitations, making Amphotericin B a preferred choice for dual or multi-drug regimens in challenging clinical scenarios.