Which antifungal is known for its quick absorption and short half-life?

Ketoconazole is indeed known for its quick absorption, particularly when taken orally. It is rapidly absorbed from the gastrointestinal tract, which allows for prompt therapeutic action. The short half-life of ketoconazole, which generally ranges from 2 to 8 hours, also contributes to its pharmacokinetic profile, making it important to maintain dosing schedules that effectively manage fungal infections.

This swift absorption is beneficial in treating acute infections where a rapid onset is advantageous. However, it's important to consider that ketoconazole's suitability has diminished over time in favor of other agents with better efficacy and fewer side effects, but its quick absorption characteristics still set it apart in certain contexts.

Other antifungals listed, like fluconazole and voriconazole, have longer half-lives and may not demonstrate the same rapid absorption rates as ketoconazole. Amphotericin B is an entirely different class of antifungal that is typically given intravenously, and while it is effective, its pharmacokinetic properties differ significantly from those of oral antifungals.