Which demographic is particularly at risk for developing fungal infections requiring antifungal therapy?

Individuals with weakened immune systems are particularly at risk for developing fungal infections requiring antifungal therapy due to their inability to effectively fight off infections. This includes patients undergoing chemotherapy, those with HIV/AIDS, organ transplant recipients, and individuals on long-term corticosteroid therapy. Fungal pathogens often thrive in environments where the immune system is compromised, leading to opportunistic infections.

In contrast, while older adults, patients with hypertension, and young children may be susceptible to various health conditions, they do not inherently possess the same level of risk for fungal infections as those with weakened immune systems. The latter group not only has a decreased ability to respond to infections but may also have prolonged hospital stays or other factors that can increase exposure to fungal pathogens in healthcare settings. Thus, the correct answer highlights a population that is significantly more vulnerable to these types of infections.