Which laboratory test is essential to monitor in patients receiving prolonged therapy with griseofulvin?

Monitoring liver function tests is essential for patients receiving prolonged therapy with griseofulvin due to the potential for hepatotoxicity associated with this antifungal agent. Griseofulvin is metabolized in the liver, and prolonged use can lead to increased liver enzyme levels, indicating possible liver damage. Regularly checking liver function tests helps in early detection of any hepatic impairment, allowing for timely intervention if needed to prevent serious complications.

While kidney function, complete blood count, and serum electrolytes are important parameters in a comprehensive patient management plan, they are not as directly impacted by the use of griseofulvin as liver function tests are. This makes liver function monitoring particularly critical during extended therapy with this medication to ensure patient safety.