Which medication could a nurse administer concomitantly to promote comfort for a client receiving amphotericin B?

Administering antipyretics alongside amphotericin B is a beneficial approach to promote comfort for a patient receiving this antifungal medication. Amphotericin B is known to potentially cause infusion-related reactions, which can manifest as fever and chills. Antipyretics, such as acetaminophen, help to reduce fever and alleviate discomfort associated with these infusion reactions, enhancing the overall tolerance of the medication.

While antibiotics, antihistamines, and antidepressants are important in various clinical contexts, they do not directly address the specific side effect profile associated with amphotericin B. Antibiotics do not play a role in managing infusion-related reactions, antihistamines may help with certain allergic reactions but are less effective for fever, and antidepressants do not relate to the acute management of infusion-related discomfort. Thus, the use of antipyretics is the most appropriate choice in this scenario.