Which of the following is a potential adverse effect of systemic antifungal therapy?

Renal toxicity is a known potential adverse effect associated with systemic antifungal therapy, particularly with certain classes of antifungal drugs like amphotericin B and some azoles. Amphotericin B is known to cause nephrotoxicity, especially with prolonged use or when given in high doses. This toxicity can manifest as a decrease in renal function, which may be indicated by rising serum creatinine levels and electrolyte imbalances. Monitoring kidney function in patients receiving systemic antifungal therapy is crucial to detect and mitigate this risk.

While other choices like hypoglycemia, hypertension, and weight gain may be associated with other medications or medical conditions, they are not commonly linked to systemic antifungal agents, making renal toxicity the most relevant option in this context. Understanding this potential adverse effect is vital for healthcare providers to ensure safe prescribing and patient management during antifungal therapy.