Which of the following is a common side effect associated with amphotericin B?

Nausea and vomiting are indeed common side effects associated with amphotericin B, which is an antifungal medication primarily used to treat serious fungal infections. Amphotericin B works by binding to ergosterol in fungal cell membranes, leading to increased permeability and cell death. However, its mechanism can also affect human cells leading to a range of non-specific side effects.

One of the significant issues with amphotericin B is that it can induce a range of adverse effects due to systemic administration, particularly affecting the gastrointestinal system. Nausea and vomiting can arise as a result of direct irritation of the gastrointestinal tract or may be related to the metabolic disturbance that can occur with the drug. These symptoms are often a major concern during treatment and can lead to reduced patient compliance if not managed properly.

Other side effects such as weight gain, headaches, or skin rashes are less commonly associated directly with amphotericin B. While they may occur occasionally or in conjunction with other medications or conditions, nausea and vomiting are more frequently observed side effects in patients receiving this drug. Understanding these common reactions is essential for managing patient care effectively during antifungal therapy.