Which of the following is a common side effect associated with amphotericin B therapy?

Amphotericin B is a polyene antifungal agent that is commonly used to treat serious fungal infections. One of the significant side effects associated with this medication is nephrotoxicity. This occurs because amphotericin B can cause damage to the renal tubules, leading to renal impairment. The mechanism of this nephrotoxicity is thought to involve the binding of the drug to cholesterol in cell membranes, which can induce inflammation and vasoconstriction, ultimately resulting in reduced renal blood flow and damage to the kidneys.

Patients undergoing amphotericin B therapy often require monitoring of renal function, including serum creatinine and electrolyte levels, to detect any early signs of nephrotoxicity. The risk of kidney damage can vary depending on the formulation of amphotericin B used and the duration of therapy, but it remains a critical consideration in managing patients receiving this antifungal treatment.

Other potential side effects like hepatotoxicity, gastrointestinal upset, and bone marrow suppression can occur with various other medications, but they are not the primary concerns associated with amphotericin B. Understanding these specific side effects helps guide clinicians in safely administering treatment and managing any adverse effects that may arise during therapy.