Which of the following statements is true regarding antifungal medications?

C is the correct answer because certain antifungal medications, particularly the azole class (such as ketoconazole and fluconazole), can have hepatotoxic effects and may require monitoring of liver function during treatment. These medications can interfere with the liver's ability to metabolize drugs, leading to potential increases in liver enzymes and affecting overall liver function. Monitoring ensures any adverse effects can be identified and managed early.

In contrast, antifungal medications are not universally suitable for all types of infections, as their effectiveness can vary based on the specific fungal pathogen involved. Additionally, while some antifungals may indeed be safe for prolonged use, it is a misconception that all are risk-free without any need for monitoring. Lastly, not all antifungals can be used systemically; some are only effective topically and are not absorbed into the systemic circulation, making the statement about all antifungals suitable for systemic use incorrect.